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Unique identifier: 215b1524-1751-4f76-8009-302eb901c5d2

1. Descrição do cargo/posição/bolsa
1. Job description


Job/Fellowship Reference: INV JR 2018.26 Nº 028147

Main research field: Biological sciences

Sub research field:

Job summary:

Main research fields:
Medical and Health Sciences and Engineering and Technology
Sub research field: Stable isotope studies of metabolism
Job summary: The position will be of 30 months duration. The applicant´s main role in the first 15 months will be to purify liver and adipose tissue triglycerides from mouse models of fatty liver disease and perform 2H and 13C NMR analyses of lipid enrichment from metabolic tracers (deuterated water and [U-13C]fructose) that were administered to the mice and applying these data to metabolic flux models of fatty acid lipogenesis and lipogenic substrate selection. Over the second 15 months, the fellow will also be involved in the NMR activities at Aveiro, where he/she will perform metabonomic and 13C-isotopomer analyses of intestinal metabolite extracts. Opening of a tender for contacting of a Ph.D. position to carry out research activities in the areas of Metabolism and Nutrition

Job description:

General scientific area: Nutrient metabolism
Specific scientific areas: Non-alcoholic fatty liver disease Stable-isotope tracer measurement of metabolic fluxes Technologies - Multinuclear NMR spectroscopy
1. The Board of Directors of the Center for Neuroscience and Cell Biology opens an international call for a doctoral post for the exercise of scientific research activities in the scientific areas of Medical and Health Sciences and Engineering and Technology, under an employment contract with uncertain term under the Labor Code, for the purpose of carrying out investigative functions under the Strategic Research Program of CNC. The selected candidate will have proven experience as a scientist, sustained by having a PI role under an active approved individual R&D project. Candidates should also have experience in R&D project management, and scientific supervision and post-graduate training of human resources. .
2. Applicable Legislation Decree No. 57/2016, of 29th of August, which approved a regime of hiring of doctorates to stimulate scientific and technological employment in all areas of knowledge (RJEC). Labor Code, approved Law no. 7/2009, of February 12, under its current version. Financed by national funds through the FCT/MCTES and co-financed by the European Regional Development Fund (ERDF), namely under the following frameworks: “Projetos de Desenvolvimento e Implementação de Infraestruturas de Investigaçãoinseridas no RNIE”; “Programa Operacional Competitividade e Internacionalização – POCI”, “Programa Operacional Centro2020”, and/or State Budget.
Job description: The job will consist of the following activities.
1) Oversight and data management of mouse feeding trials where the effects of high fat, high sugar or a high fat and sugar combination on the development of non alcoholic fatty liver disease (NAFLD) will be studied.
2) Implement stable isotope tracer studies of hepatic sugar and fat metabolism into these feeding trials using deuterated water and 13C-enriched fructose.
3) Isolate and analyze liver and adipose tissue triglyceride 13C and 2H enrichments by NMR spectroscopy after post mortem harvesting from these animals.
4) Isolate and analyze the composition of intestinal metabolites and their 13C and 2H enrichments by NMR spectroscopy after post mortem harvesting from these animals.
5) Develop metabolic models for determining the contribution of fructose to hepatocyte de novo lipogenesis and Krebs cycle fluxes and to intestinal microbial metabolism.
6) Curate, report and present the scientific data in peer-reviewed scientific journals and meetings.

3. The selection panel shall be: Chairman of the Jury: John Griffith Jones, Jury Members: Paulo Oliveira and Armindo Salvador, Deputy Juri members: Eugenia Carvalho and Carlos Palmeira.
4. Place of work: Center for Neuroscience and Cell Biology, headquartered at University of Coimbra, Polo I, and/or its research extensions at Polo III and UC-Biotech (at Cantanhede)
5. The monthly salary is set in accordance with the provisions in RJEC, article 15, no. 1, corresponding to level 33 of the single salary scale approved by Decree no. 1553-C/2008 of the 31st December, at 2,128.34 Euros gross.

6. Applicants may be Nationals, Foreign and Stateless candidates who hold a doctorate degree in Biosciences and related fields. Applicant should hold a scientific and professional curriculum that reveals a profile appropriate to the activity to be developed. In case of doctorate degrees awarded by a foreign higher education institution, said degree must comply with the provisions of Decree-Law no. 341/2007 of 12 October, and all formalities established therein must be fulfilled at the deadline for application submission

7. General admission requirements: Degree of Doctor in Biosciences and related fields. Excellent track record in his/her research area. Excellent knowledge of English (oral and written). Animal experimentation certification accredited by the Portuguese National Authority for Animal Health (DGAV).

8. The selection is made through the evaluation of the scientific and curricular path of the candidates.

9. The selection of PhD holders to be contracted will be carried out through assessing the academic and curricular vitae of the candidates for the Position in the tender. In general terms, this evaluation will concern relevance, quality and state of the art: a) of the scientific and technological production considered more relevant by the candidate; b) of his/her active role as a PI on competitively funded R&D projects; c) Of the activities regarding the extension and dissemination of knowledge carried out in the last five years, specifically in the context of promoting culture and scientific practices, considered of greatest importance by the candidates, connected with the Positions in the tender.

10. The tender has been opened for the position listed in the following paragraph; This position is designed to carry out a plan of research activities and dissemination of knowledge in Metabolism and Nutrition, and be focused on stable isotope tracer studies of carbohydrate and lipid metabolism in animal models of fatty liver disease with the objective of understanding the role of extrahepatic tissues in promoting non-alcoholic fatty liver disease during high sugar and/or fat feeding. The working plan is expected to further extend the knowledge on the chosen topic, reinforcing the activities and international presence of CNC in the field of non-alcoholic fatty liver disease. It should also be aligned with CNC's strategy for the period 2018-2022 and take into account the interests and internal dynamics of its research groups.

11. The scientific and curricular career are targets of evaluation criteria. The evaluation of the CV of the candidates, in particular the content of the scientific publication, the scientific merit and research capacity in the project area will be made according to the following criteria:

11.1 Integrated assessment of the curriculum trajectory of the candidate, based on an overview of his / her scientific and communication merits - 90% in total. The following items will be herein evaluated: 1) consistency and quality of CV – 10 %; 2) Content and quality of the scientific production published by the candidate in international journals in his/her the area of expertise – 10% (decomposed as: number of first or corresponding author publications; number of citations, and accumulated impact factor); 3) Principal investigator in research projects in the scientific area – 50 %; 4) Access to international networks and involvement in international consortia – 10% 5) Participation in activities of knowledge dissemination and exploitation – 10%, including organization and active participation in scientific courses and meetings, and scientific mentoring, including of PhD and MSc thesis and participation in thesis committees
11.2 – Interview – 10% 12. The final classification system for candidates is expressed on a scale of 0 to 100.
13. The jury shall deliberate by means of a nominal vote based on the selection criteria adopted and published, and abstentions shall not be allowed. 14. The panel meetings will be documented in written minutes, containing a summary of what has taken place, as well as the votes cast by each of the members and their reasons, being provided to the candidates whenever requested.
15. After applying the selection criteria, the panel will prepare a sorted list of approved candidates with their classification.
16. The final decision of the jury is approved by the leader of the institution that is also in charge of deciding about hiring.
17. Formalization of the applications:
17.1 Applications are formalized by sending a letter addressed to the President of the Jury, stating this announcement identification, full name, parents’ names, number and date of identity card, Citizen Card, or civil identification number and date, taxpayer ID number, date and place of birth, marital status, occupation, residence and contact address, including e-mail address and telephone contact.
17.2. Applicant must clearly state to which position they are applying to.
17.3 The application shall include all supported documents encompassed by section 6 and 7 for admission to this competition, namely:
a) Copy of certificate or diploma; B) Doctorate thesis; C) Detailed curriculum vitae, structured in accordance with items 10 and 11; D) Other documents relevant for the evaluation of the qualification in related scientific area; E) Brief description of the most relevant scientific activities of the last 5 years (max. 1 page), according to item 10 of this announcement.
17.4 Applicants should send their applications by post, to the address Centro de Neurociências e Biologia Celular, Departamento de Recursos Humanos, Rua Larga, FMUC, 1º Piso, Universidade de Coimbra, 3004-504 Coimbra, Portugal. The mail must be registered, with notice of receipt, issued until the last day of the deadline for opening the tender, which is set at 30 working days after publication of this call. (31/10/2018).
18. All candidates who formalize their applications in an improper way or fail to prove the requirements imposed by this tender are excluded from admission. In case of doubt, the panel is entitled to request any candidate to present further documentation supporting their statements.
19. False statements by candidates shall be punished by law.
20. The list of admitted and excluded candidates as well as the final classification list are posted in CNC’s webpage at http://www.cnbc.pt/, and the applicants will be notified by email with receipt of delivery of the notification.
21. Preliminary Hearing and deadline for Final Decision: After notification of the results, the candidates have 10 working days to respond. In the next 2 working days, counted from the deadline for submitting complaints, the final decisions of the jury shall be published on the CNC's website: http://www.cnbc.pt/.
22. The present tender is exclusively destined to fill the vacancy indicated and may be terminated until the homologation of the final ranking list of candidates and expires with the respective occupation of the job on offer.
23. Non-discrimination and equal access policy: The CNC actively promotes a policy of non-discrimination and equal access, so that no candidate can be privileged, beneficiary, disadvantaged or private of any right or exemption from any duty owing, in particular, to ancestry, age, sex, sexual orientation, marital status, family situation, economic situation, education, social origin or condition, genetic heritage, reduced working capacity, disability, chronic illness, nationality, ethnic origin or race, territory of origin, language, religion, political or ideological beliefs and trade union membership.
24. Under the terms of D.L. No. 29/2001, of February 3, the candidate with disability has a preference in equal classification, which prevails over any other legal preference. Candidates must declare their respective degree of disability, the type of disability and the means of communication / expression to be used in the selection process, under the terms of the aforementioned diploma, on the application form. 25. Under the terms of the RU 2016/679 27/04/2016 and Law nº 67/98 26/10 the personal data collected by the entity is for recruitment purposes only. Personal data collected by the entity by means of this application are intended to assess whether candidates are suitable for the place requested and for the preliminary calculation of the remuneration, bonuses and perks of the candidates who are admitted to the recruitment. The data entered in the application are essential data in the weighting of the selection of candidates, which may affect the efficiency and the result of the respective application if the candidates do not provide them. Personal data of unsuitable candidates will be retained by the entity for a period of five years for subsequent recruitment. Applications for candidates may be transferred by the entity to its own premises or to the entities of the consortium where there are job openings during the abovementioned period. Candidates shall enjoy, in accordance with the law, the rights of access and rectification. For the exercise of the right of access, they must submit the request in writing to the person in charge of the entity.

Vacant posts: 1

Type of contract: To be defined

Job country: Portugal

Job city: Coimbra

Job company/institute: Centro de Neurociencias e Biologia Celular

Application deadline: 31 Outubro 2018
(The Application's deadline must be confirmed on the Job Description)

2. Dados de contactos da organização
2. Organization contact data

Organization/institute: Centro de Neurociências e Biologia Celular

Rua Larga, FMUC, 1ºPiso
Coimbra - 3004-504

Email: info@cnc.uc.pt

Website: http://www.cnbc.pt/

3. Habilitações académicas
3. Required education Level

Degree: Applicants may be Nationals, Foreign and Stateless candidates who hold a doctorate degree in Biosciences and related fields. Applicant should hold a scientific and professional curriculum that reveals a profile appropriate to the activity to be developed. In case of doctorate degrees awarded by a foreign higher education institution, said degree must comply with the provisions of Decree-Law no. 341/2007 of 12 October, and all formalities established therein must be fulfilled at the deadline for application submission
Degree field: Biological sciences
4. Línguas exigidas
4. Required languages

Language: English
Priority: High
Reading: Excelent
Writing: Excelent
Comprehension: Excelent
Conversation: Excelent
5. Experiência exigida em investigação
5. Required research experience