Field of study:

Job description:

Work plan:

The Postdoctoral Researcher will participate in developing a novel cellular model of late-onset Alzheimeir’s disease using human neurons differentiated from hIPSCs edited with CrisPR-CAS9 with the patient’s mutations, to evaluate how Alzheimer’s late-onset mutations disrupt neuronal function. The preferred language of communication will be English.

This project will include a broad and evolving range of tasks, including:

- Advanced cell culture technology

-- quantitative single cell microscopy

- Synapse and endosomal trafficking techniques

- writing and publishing under guidance

- Developing academic independence

- Dissemination and communication of results                                

Legislation and applicable regulations:

The fellowship is awarded under Law 40/2004, of 18 August (Statute of the Scientific Research Fellow) and the Fellowships and Research Regulations of the Foundation for Science and Technology in force.

Field of study:

Job description:

Work plan:

The Postdoctoral Researcher will participate in developing a novel cellular model of late-onset Alzheimeir’s disease using human neurons differentiated from hIPSCs edited with CrisPR-CAS9 with the patient’s mutations, to evaluate how Alzheimer’s late-onset mutations disrupt neuronal function. The preferred language of communication will be English.

This project will include a broad and evolving range of tasks, including:

- Advanced cell culture technology

-- quantitative single cell microscopy

- Synapse and endosomal trafficking techniques

- writing and publishing under guidance

- Developing academic independence

- Dissemination and communication of results                                

Legislation and applicable regulations:

The fellowship is awarded under Law 40/2004, of 18 August (Statute of the Scientific Research Fellow) and the Fellowships and Research Regulations of the Foundation for Science and Technology in force.

Place of work:

The work will be developed at the Laboratory “Neuronal Trafficking in Aging” at the Center for the Study of Chronic Diseases at NOVA Medical School | Faculty of Medical Sciences at Universidade NOVA de Lisboa, under the scientific guidance of Dr. Cláudia Almeida (PI).

Fellowship duration

The scholarship will run for 6 months, starting on April 1, 2021.

The scholarship contract is eventually renewed for an equal period until the end of the project (3 years).

Monthly maintenance allowance amount:

The amount of the fellowship corresponds to € 1,616.00 monthly (tax-free), paid monthly by bank transfer, according to the table of values of fellowships directly attributed by FCT, I.P. in the country.

Selection methods:

The selection methods to be used are as follows:

Candidates will be screened for eligibility according to admission requirements listed. The evaluation will consist of 3 stages:

1.       Candidates will be scored and shortlisted according to the required application materials (motivation letter and CV). The value is calculated by weighing in each factor as follows scientific and curricular background (40%), expertise in the work field (40%), and motivation letter (20%).

Please consider when preparing your application, the preferred Candidate profile:

Ability to state scientific motivation

Ability to drive and work independently on a research project

Good capacity for teamwork, critical thinking, and communication skills

Fluency in English

Willing to collaborate with colleagues

Research Integrity

Desirable skills and experience that will also be considered (please indicate in the CV):

hIPSCs cell culture

Human neurons differentiation from hiPSCs

Neuronal activity techniques (i.e Calcium imaging, electrophisiology, Multi-Electrode arrays, Phluorins, FM1-43).

Imaging techniques (i.e confocal, super-resolution, live imaging)

Quantitative image analysis (i.e. Fiji, Imaris)

Programming skills (i.e. Matlab, Python)

2.       Candidates with the best score in 1. will be contacted for a short-written assignment.

3.       The candidates that obtain the highest scores in 2. will be interviewed (remotely), and referees will be contacted. Candidates who are interviewed will be assigned a new classification.The top candidate will be selected based on the presentation (40%), previous work (30%) and questions (30%).

Composition of the Selection Jury:

Doctor Cláudia Almeida - President of the Jury

Doctor Hugo Vicente Miranda - effective vowel

Professor Rita Teodoro - effective vowel

Professor Paulo Pereira - alternate member

Doctor César Mendes - alternate member

Publication / notification of results:

The final results of the evaluation will be sent by email to candidates who submit a valid application.

Application deadline and form of submission of applications:

The competition is open from February 23 to March 8, 2021.

Applications must be sent by email to applications@nms.unl.pt, mentioning the reference of Bolsa DAI / 2021/05 in the Subject / Subject of the message.

Applications must be formalized, mandatorily, by sending a Motivation Letter accompanied by the following documents: 1. Motivation Letter

2. Short Curriculum Vitae identifying the elements indicated in the desired profile when possible.

3. Copy of the qualification certificate.

FCM reserves the right not to award the proposed scholarship to the competition if the candidates do not meet the requirements indicated in this notice.