6. Selection Committee
Assistant Professor of Biophysics, Faculty of Medicine, University of Coimbra, Portugal
Director of IBILI, Faculty of Medicine, Coimbra, Portugal.
Visual Neuroscience Laboratory
IBILI, Institute for Biomedical Research on Light and Image
Faculty of Medicine
University of Coimbra
Azinhaga de Sta Comba
Tel: + 351. 239 - 480261
Fax: + 351. 239 – 480280
Mobile + 351 936350050
MCB is now Assistant Professor at the University of Coimbra, Portugal, and has held a similar position in 2000 at the University of Maastricht, the Netherlands. Before (1998-1999), he was a Postdoctoral fellow at the Max-Planck-Institut für Hirnforschung, Germany where he had also performed his PhD work (1994-1998).
He has made contributions in the fields of Ophthalmology, Neurology, Visual Neuroscience, Human Psychophysics, Functional Brain Imaging and Human and Animal Neurophysiology. His lab is now accomplishing tasks also in the context of a European Network (Evi-Genoret), and has succeed in collaborating with labs working in other fields of knowledge such as Human Genetics and Clinical Neuroscience. He is the scientific coordinator of the National Functional Brain Imaging Network. In his work he could isolate specific magnocelullar/visual motion dysfunction in a genetic neurodevelopmental model, Williams Syndrome. He has further studied parallel pathways to quantitatively analyze visual aging in neurodegenerative disorders of the retina and the brain (Glaucoma and Parkinson Disease). His laboratory is very experienced in Visual Impairment questions, and the multiple causes of amblyopia and its functional characterization in centre and peripheral visual field. In recent work, the lab has characterized genetic and acquired photoreceptor retinal degenerations. One major goal is to provide models of visual impairment based on new structure-function and genotype-phenotype correlations (that may help define new biomarkers for retinal degenerations). He has also published work on neuropsychology and psychophysics in patient populations. His achievements are well reflected in publications in top General Journals, such as Nature and PNAS and Top Translational research journals such as Journal of Clinical Investigation (impact factor(IF): 15,8), Brain (IF 8) as well as others in the field of Basic and Clinical Visual Sciences.
Figueiredo P, Teixeira J, Santana I, Cunha C, Machado E, Castelo-Branco M (2008) Visual memory reorganization in right medial temporal lobe pathology Epilepsia Apr 28. [Epub ahead of print]
Silva MF, Maia-Lopes S, Mateus C, Guerreiro M, Sampaio J, Faria P, Castelo-Branco M. Retinal and cortical patterns of spatial anisotropy in contrast sensitivity tasks. (2008) Vision Research 48(1):127-35.
Maia–Lopes S., Silva E., Silva M.F., Reis, A. Faria P. & Castelo–Branco M. (2008) Evidence for widespread retinal dysfunction in patients with Stargardt disease and morphologically unaffected carrier relatives Investigative Ophthalmology and Visual Sciences, 49(3):1191-9.
Castelo-Branco M, Mendes M, Sebastião AR, Reis A, Soares M, Saraiva J, Bernardes R, Flores R, Pérez-Jurado L, Silva E. (2007) Visual phenotype in Williams-Beuren syndrome challenges magnocellular theories explaining human neurodevelopmental visual cortical disorders. The Journal of Clinical Investigation 117(12):3720-9.
Biederlack J, Castelo-Branco M, Neuenschwander S, Wheeler DW, Singer W, Nikolic D. (2006) Brightness induction: rate enhancement and neuronal synchronization as complementary codes. Neuron 21;52(6):1073-83.
Schmidt KE, Castelo-Branco M, Goebel R, Payne BR, Lomber SG, Galuske RA. Pattern motion selectivity in population responses of area 18. (2006) European Journal of Neuroscience 24(8):2363-74.
Castelo-Branco, M. Silva, M. F. Januário C.& Freire A. (2006) Concomitant impairment of multiple visual pathways in Parkinson’s disease Brain 129(12):e62
Castelo-Branco M, Mendes M, Silva MF, Januário C, Machado E, Pinto A, Figueiredo P, Freire A. (2006) Specific retinotopically based magnocellular impairment in a patient with medial visual dorsal stream damage. Neuropsychologia 44(2):238-53.
Silva MF, Faria P, Regateiro FS, Forjaz V, Januário C, Freire A, Castelo-Branco M. (2005) Independent patterns of damage within magno-, parvo- and koniocellular pathways in Parkinson's disease. Brain 128(Pt 10):2260-71. Epub 2005 Jul 6.
Mendes M, Silva F, Simões L, Jorge M, Saraiva J, Castelo-Branco M. (2005)Visual magnocellular and structure from motion perceptual deficits in a neurodevelopmental model of dorsal stream function. Cognitive Brain Research 25(3):788-98. Epub 2005 Oct 26.
Campos SH, Forjaz V, Kozak LR, Silva E, Castelo-Branco M. (2005) Quantitative phenotyping of chromatic dysfunction in best macular dystrophy. Archives of Ophthalmology 123(7):944-9.
Castelo-Branco M. (2005) Neural correlates of visual hallucinatory phenomena: The role of attention Behavioral & Brain Sciences 2005 Dec;28(6):760-1.
Castelo-Branco M, Faria P, Forjaz V, Kozak LR, Azevedo H. (2004) Simultaneous comparison of relative damage to chromatic pathways in ocular hypertension and glaucoma: correlation with clinical measures. Investigative Ophthalmology and Visual Sciences 45(2):499-505.
Castelo-Branco, M. Formisano, E. Backes, W. Zanella, F. Neuenschwander, S., Singer, W. & Rainer Goebel (2002) Activity patterns in human motion sensitive areas depend on the interpretation of global motion Proceedings of Nacional Academy of Sciences, USA, 99(21): 13914-13919.
Neuenschwander, S., Castelo-Branco, M., Baron J. & Singer W. (2002) Feedforward synchronization: Propagation of temporal patterns along the retinothalamocortical pathway, Phil. Trans. Of the R. Soc. of London: Biological Sciences, UK 357 (1428): 1869-1876
Castelo-Branco M., Goebel, R. Neuenschwander S., and Singer W. (2000) Neural synchrony reflects surface segmentation rules. Nature 405(6787):685-689.
Neuenschwander S., Castelo-Branco M. and Singer W. (1999) Synchronous oscillations in the cat retina Vision Research Jul; 39(15):2485-97.
Castelo-Branco M., Neuenschwander S., and Singer W. (1998) Synchronization of visual responses between the visual cortex, the lateral geniculate nucleus and the retina in the anhesthetized cat. The Journal of Neuroscience Aug 15; 18(16): 6395-6410