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6. Juri
6. Selection Committee

Nome
Name
- Prof. André Goffeau, Institut des Sciences de la Vie, Louvain-la-Neuve, Belgium


CV (Português)
CV (Portuguese)




CV(Inglês)
CV (English)
GOFFEAU André Born: January 26, 1935, Ixelles, Belgium Private address: Gemslaan 51, B-3090 Overijse, Belgium Tel: 32-2-687 66 23 Work address: Croix du Sud, 5/15, B-1348 Louvain-la-Neuve, Belgium
Tel: 32-10-47 36 14 Fax: 32-10-47 38 72
E-mail: goffeau@fysa.ucl.ac.be

Degrees
. Ingénieur Agronome (Master in Agronomy), 1956, Université catholique de Louvain.
. Docteur en Sciences Botaniques, 1964, Université catholique de Louvain
. Agrégé de l'Enseignement Supérieur, 1969, Université catholique de Louvain

Postdoctoral Trainings
. Sept 1963 - Aug 1964: Laboratoire de Morphologie Animale de l'Université Libre de Bruxelles, Belgium (Professor Jean Brachet)
. Sept 1964 - Jun 1966: Department of Physiological Chemistry of the John Hopkins
School of Medicine, Baltimore, USA (Professor Albert Lehninger)
. Feb 1967 - Aug 1969: Institut National Agronomique, Laboratoire de Génétique, Paris, France (Professor Henri Heslot)

Current Position : retired professor at the Université catholique de Louvain

Previous Positions
. "Professeur extraordinaire" at the Université catholique de Louvain (1969 to 1999) and jointly Scientific Officer of the Commission of European Communities in Brussels (1961 to 1997)

Scientific Interests
. H+ transport ATPases in yeast
. Multidrug ATPases in yeast
. Sequencing and analysis of the yeast genome

Membership of Scholar Societies
. Comité des Applications de l'Académie des Sciences Françaises (correspondent-until 2000)
. Brazilian Academy of Sciences (correspondent)
. Académie Royale des Sciences, des Lettres et des Beaux-Arts de Belgique (associate)
. Académie des Sciences de l'Institut de France (associate)
. European Molecular Biology Organization (EMBO)
. The Johns Hopkins Society of Scholars, USA (1998)

Awards
. Prix Quinquennal Jean Maisin du Fonds National de La Recherche Scientifique, Belgium (1986-1990)
. Honorary Fellow from the University of Manchester, UK (1993)
. Gold Medal from the University of Wroclaw, Poland (1997)
. Hansen Gold Medal, Denmark (1998)
. The Rotschild-Yvette Mayent-Institut Curie Award, France (1999)
. The Human Frontier Science Programm 10th Anniversary Award, France (1999)
. The International Research Chair « Blaise Pascal », France (2000–2001)
. Dr Honoris Causa University Pierre et Marie Curie, France (2001)
. Gold Medal from the Charles University, Praha (2001)
. George Beadle Medal from the Genetics Society of America (2002)
. “The Golden Yeast” award from the French-speaking Yeast Geneticists, Geneva (2002)
. Dr Honoris Causa Comenius University, Bratislava (2004)
. Dr Honoris Causa Wroclaw University, Poland (2004)
Honorary Lectures
. Antonie van Leeuwenhoek Lecturer of the Nederlandse Vereniging voor Microbiologie,
Leiden, The Netherlands (1990)
. Chaire Francqui, Université Libre de Bruxelles, Belgium (1992)
. Fifth Albert L. Lehninger Lecturer (The Johns Hopkins University), USA (1998)
. Ladeuze Conference, Université catholique de Louvain, Brussels, (2000)
. Magni Lecture, Adriano Buzzati Traverso Foundation, University of Milano, (2002)
. Ida Cordelia Beam Distinguished Seminar, University of Iowa, (2002)
. Jornadas van Uden Lecture, Instituto Superior de Agronomia, University of Algarve,
Lisboa (2002)

Publications
. From 1960 to 2006, a total of 284 full papers in reviewed journals were authored, as well as an autobiography (G. Semenza and A.J Turner Eds., Comprehensive Biochemistry Vol. 43, 2004).

Editorial Boards of Scientific Journals
. Journal of Bioenergetics and Biomembranes (1981-1991)
. Current Genetics (1991-1999)
. Yeast (1993- )
. Principal editor for yeast genetics in TheScientificWorld (2000)
. Journal of Molecular Microbiology and Biotechnology (2000- )
. Biochemical and Biophysical Research Communications (2001-2006)
. Functional and Integrative Genomics (2001- )
. Genome Biology (2003- )
. FEMS Yeast Research (2004- )

Scientific Councils and Boards
. 1979-1981 Treasurer of the Société Belge de Biochimie
. 1980 Organizer of the Tenth International Conference on Yeast Genetics and Molecular Biology (Louvain-la-Neuve, 475 participants)
. 1987 Organizer of the Fifth Small Meeting on Yeast Transport and Energetics (Louvain-la-Neuve, 75 participants)
. 1989 Organizer of the first Biotechnology Action Programme Meeting on
Sequencing the Yeast Genome (Louvain-la-Neuve, 60 participants)
. 1987 Chairman of the Division Biotechnologie de la Société Chimique de Belgique
. 1987-1991 Member of the Comité de Direction du Centre de Génétique Moléculaire du Centre National de la Recherche Scientifique, Gif-sur-Yvette, France
. 1987-1990 Member of the International Committee for the Feasibility Study of the Human
Frontier Science Programme, Tokyo, Japan
. 1989- Member of the Science Council for the Human Frontier Science Programme
Organization, Strasbourg, France
. 1989 Organizer of the first Biotechnology Action Programme Meeting on
Sequencing the Yeast Genome (Louvain-la-Neuve, 60 participants)
Programme, Strasbourg, France
. 1991-1994 Member of the Board of Directors of the International Institute of
Biotechnology, London, UK
. 1991-1992 Member of the Comité Scientifique d'Evaluation du Département de Biologie
Moléculaire de l'Institut Pasteur, Paris, France
. 1992-1995 Member of the Conseil Scientifique du Groupement de Recherches et
d'Etudes sur les Génomes, Ministère de la Recherche et de l'Espace
Gif-sur-Yvette, France
. 1993 Organizer of the first BRIDGE-BIOTECH Meeting on Sequencing the Yeast
Genome (Louvain-la-Neuve, 120 participants)
. 1993-1995 Vice Chairman of the Review Committee of the Human Frontier Science
Programme, Stasbourg, France
. 1993 Organizer of the first BRIDGE-BIOTECH Meeting on Sequencing the yeast
Genome (Louvain-la-Neuve, 120 participants)

. 1993-1994 Member of the Comité Scientifique auprès du Ministère de l'Education
Nationale et de la Culture, Paris, France
. 1994-1995 Member of the Comité Scientique de l'Unité Propre de Recherche du Centre
National de la Recherche Scientifique "Mécanismes Moléculaires
de la Division Cellulaire et du Développement", Strasbourg, France
. 1994 Member of the International Advisory Board of the Departement de Biologie Moléculaire et Structurale du CEA, Grenoble, France
. 1994 Member of the Comité Scientifique du Laboratoire de "Reconnaissance
Moléculaire et Catalyse" du Centre National de la Recherche Scientifique,
Compiègne, France
. 1994- Member of the Scientific Advisory Board of the Groningen Biomolecular
Sciences and Biotechnology Institute, Groningen, The Netherlands
. 1995 Member of the Advisory Council of BioCentrum, Amsterdam, The Netherlands
. 1995 Member of the Comité Scientifique de l'Unité Propre de Recherche du Centre
National de la Recherche Scientifique "Recombinaisons Génétiques",
Rennes, France
. 1995-1997 Co-chairman of the Seventh, Eight and Ninth International Genome
Sequencing and Analysis Conferences (Hilton Head, USA, 700 to 1200
participants)
. 1997 Member of the Nominating Committee ot the International Union of
Biochemistry and Molecular Biology
. 1997 Member of the Scientific Council of the "Centre de Recherche Agronomique
de Gemboux", Belgium
. 1997 Member of the International Steering Committee for the Bacterial Genome
Sequencing project of the Foundation for the Support of
Research of the State of Sao Paulo (FAPESP), Brazil
. 1998 Member of the Comité Scientifique d'Evaluation du Département des
Biotechnologies, Institut Pasteur, Paris, France
. 1998-1999 Chairman of the Société Belge de Biochimie et de Biologie Moléculaire.
. 1999 Co-chairman of the Third Annual Conference on Microbial Genomes
(Chantilly, USA)
. 2000-2001 Member of the Oversight Committee for the National Genome Project
organized by the Brazilian Ministry of Science and Technology
. 2001-2003 Reviewer of the Genome Québec project organized by the Fonds de la
recherche en santé du Québec
. 2001 Member of the "Comité Scientifique pour la création d'un Centre de
Recherches Interdisciplinaire à Lille", France
. 2002-2004 Advisory board of the Center for Eukaryotic Structural Genomics,
University of Wisconsin-Madison, USA
. 2005 Member of the review panel of the University of Würzburg, Germany,
. 2005 Member of the Comité Scientifique d’évaluation de l’Unité NOPA
(Neurobiologie de l’Olfaction de la Prise Alimentaire), INRA, Jouy-en-Josas,
France
. 2006 Organizer of the 10th anniversary of the Yeast Genome meeting, Brussels,
Belgium
. 2007 Organizer of the Yeasterday Meeting, Louvain-la-Neuve, Belgium



Key Publications

Proton-ATPases

• Dufour, J.-P. and Goffeau, A.
Solubilization by lysolecithin and purification of the plasma membrane ATPase
of the yeast Schizosaccharomyces pombe.
J. Biol. Chem. 254, 7026-7032 (1978)


• Amory, A., Foury, F. and Goffeau, A.
The purified plasma membrane ATPase of the yeast Schizosacharomyces pombe
forms a phosphorylated intermediate.
J. Biol. Chem. 255, 9353-9357 (1980)

• Villalobo, A., Boutry, M. and Goffeau, A.
Electrogenic proton translocation coupled to ATP hydrolysis by the plasma
membrane ATPase of yeast in reconstituted proteoliposomes.
J. Biol. Chem. 256, 12081-12087 (1981)

• Amory, A., Goffeau, A., McIntosh, D.B. and Boyer, P.D.
Exchange of oxygen between phosphate and water catalysed by the plasma
membrane ATPase from the yeast Schizosaccharomyces pombe.
J. Biol. Chem. 257, 12509-12516 (1982)

• Schlesser, A., Ulaszewski, S., Ghislain, M., and Goffeau, A.
A second transport-ATPase gene in Saccharomyces cerevisiae.
J. Biol Chem . 263, 19480-19487 (1988)

• Ghislain, M., and Goffeau, A.
The pma1 and pma2 H+-ATPases from Schizosaccharomyces pombe are
functionally interchangeable.
J. Biol. Chem. 266, 18276-18279 (1991)

• Morsomme, P.,…, Goffeau, A. and Boutry, M.
Single point mutations in various domains of a plant plasma membrane H+-ATPase expressed in Saccharomyces cerevisiae increase H+-pumping and permit yeast growth at low pH.
EMBO J. 15, 5513-5526 (1996)

• Morsomme, P., Chami, M., Marco, S., Nader, J., Ketchum, K.A., Goffeau, A. and Rigaud, J.
Characterization of a hyperthermophilic P-type ATPase from Methanococcus
jannaschii expressed in yeast
J. Biol. Chem. 277, 29608-29616 (2002)

• Ferreira-Pereira, A., Marco, S., Decottignies, A., Nader, J., Goffeau, A., and
Rigaud, J.
Three-dimensional reconstruction of the Saccharomyces cerevisiae multidrug resistance protein Pdr5p
J. Biol. Chem. 278, 11995-11999 (2003)


New Plasma Membrane Proteolipids

• Navarre, C., Catty, P., Leterme, S., Dietrich, F., and Goffeau, A.
Two distinct genes encode small isoproteolipids affecting plasma membrane H+-ATPase
activity of Saccharomyces cerevisiae.
J. Biol. Chem. 269, 21262-21268 (1994)

• Navarre, C. and Goffeau, A.
Membrane hyperpolarization and salt sensitivity induced by deletion of PMP3, a highly conserved small protein of yeast plasma membrane.
EMBO J. 19, 2515-2524 (2000)





Pleiotropic Drug Resistance

• Balzi, E., Wang, M., Leterme, S., Van Dyck, L. and Goffeau, A.
PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1.
J. Biol. Chem. 269, 2206-2214 (1994)

• Decottignies, A., Kolaczkowski, M., Balzi, E. and Goffeau, A.
Solubilization and characterization of the overexpressed PDR5 multidrug resistance nucleotide triphosphatase of yeast.
J. Biol. Chem. 269, 12797-12803 (1994)

• Decottignies, A., Lambert, L., Catty, P., Degand, H., Eppings, E.A., Scott Moye-Rowley,
W., Balzi, E., and Goffeau, A.
Identification and characterization of SNQ2, a new multidrug ATP binding cassette
transporter of the yeast plasma membrane.
J. Biol. Chem. 270, 18150-18157 (1995)

• Kolaczkowski, M., Van der Rest, M., Cybularz-Kolaczkowsko, A.,
Soumillion, J.-P., Koning, W.N., and Goffeau, A.
Anticancer drugs, ionophoric peptides, and steroids as substrates of the yeast
multidrug transporter Pdr5p.
J. Biol. Chem. 271, 31543-31549 (1996)

• Decottignies, A. and Goffeau, A.
Complete inventory of the yeast ABC proteins.
Nature Genetics, 15, 137-145 (1997)

• Decottignies, A., Grant, A.M., Nichols, J.W., De Wet, H., McIntosh, D.B., and Goffeau, A.
ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p.
J.Biol. Chem. 273, 12612-12622 (1998)


Genomes

• Oliver, S.G.,…Goffeau, A.,... and Sgouros, J.
The complete DNA sequence of yeast chromosome III.
Nature 357, 38-46 (1992)

• Goffeau, A., Barrell, B.G., Bussey, H., Davis, R.W., Dujon, B., Feldmann, H.,
Galibert, F., Hoheisel, J.D., Jacq, C., Johnston, M., Louis, E.J., Mewes, H.W.,
Murakami, Y., Philippsen, P., Tettelin, H. and Oliver, S.G.
Life with 6000 genes.
Science 274, 546-552, (1996)

• Goffeau, A. and 642 other authors
The yeast genome directory.
Nature 387 (suppl.) 1-105 (1997)

• Dujon, B.,…Goffeau, A., and Mewes, H.W.
Complete DNA sequence of yeast chromosome XI.
Nature Nature, 371-378 (1994)


• Feldmann, H.,…, Goffeau, A.,…, and Kleine, K.
Complete DNA sequence of yeast chromosome II.
EMBO J. 13, 5795-5809 (1994)

• Galibert, F…., Goffeau, A.,…, and Karpfinger-Hartl, L.
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.
EMBO J. 15, 2031-2049 (1996)

• Jacq, C.,…, Goffeau, A., …, and Zaccaria, P.
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
Nature 387, (suppl.) 75-78 (1997)

• Tettelin, H.,…, Goffeau, A.,…, and Kleine, K.
The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.
Nature 387, (suppl.) 81-84 (1997)

• Johnston, M.,..., Goffeau, A.,…, and Hoheisel, D.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.
Nature 387, (suppl.) 87-90 (1997)

• Philippsen, P.,…, Goffeau, A.,…, and Hani, J.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.
Nature 387, (suppl.) 93-98 (1997)

• Dujon, B.,…, Goffeau, A.,…, and Kleine, K.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.
Nature 387, (suppl.) 98-102 (1997)

• Bussey, H…., Goffeau, A.,…, and Hani, J.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
Nature 387, (suppl.) 103-105(1997)

• Kunst, F., ..., Goffeau, A.,..., and Danchin, A.
The complete sequence of the Gram-positive bacterium Bacillus subtilis.
Nature 390, 249-256 (1997)

• Capela, D., ...,., Goffeau, A.,..., and Galibert, F.
Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021.
PNAS USA 98, 9877-9882 (2001)

• Galibert, F., ..., Goffeau, A., ..., and Batut, J.
The composite genome of the legume symbiont Sinorhizobium meliloti.
Science 293, 668-672 (2001)

• Wood, V., …, Goffeau, A.,… and Nurse, P.
The genome sequence of Schizosaccharomyces pombe.
Nature 415, 871-880 (2002)


• Wood, V., …, Goffeau, A.,… and Nurse, P.
The genome sequence of Schizosaccharomyces pombe.
Nature 415, 871-880 (2002)

• Bolotin, A.,…, Goffeau, A. and Hols, P.
Complete sequence and comparative genome analysis of the dairy bacterium.
Nat. Biotechnol. 22, 1154-1158 (2004)

• Ivens, A., …, Goffeau, A.,... and Myler P.
The genome of the kinetoplastid parasite, Leishmania major.
Science 309, 436-442 (2005)

• De Hertogh, B., Hancy, F., Goffeau, A. and Baret, P.
Emergence of species-specific transporters during evolution of the hemiascomycete phylum.
Genetics 172, 1092-1093 (2006)




And over 30 papers on analysis of the yeast genome and in particular membrane protein-encoding genes.